HZA106837 was of variable treatment duration (from a minimum of 24 weeks to a maximum of 76 weeks with the majority of patients treated for at least 52 weeks). In HZA106837 patients were randomised to receive either fluticasone furoate/vilanterol 92/22 micrograms [n=1009] or FF 92 micrograms [n=1010] both administered once daily. In HZA106837 the primary endpoint was the time to first severe asthma exacerbation. A severe asthma exacerbation was defined as deterioration of asthma requiring the use of systemic corticosteroids for at least 3 days or an inpatient hospitalization or emergency department visit due to asthma that required systemic corticosteroids. Adjusted mean change from baseline in trough FEV 1 was also evaluated as a secondary endpoint.
Heavy consumption of the essential amino acid lysine (as indicated in the treatment of cold sores) has allegedly shown false positives in some and was cited by American shotputter C. J. Hunter as the reason for his positive test, though in 2004 he admitted to a federal grand jury that he had injected nandrolone.  A possible cause of incorrect urine test results is the presence of metabolites from other AAS, though modern urinalysis can usually determine the exact steroid used by analyzing the ratio of the two remaining nandrolone metabolites. As a result of the numerous overturned verdicts, the testing procedure was reviewed by UK Sport . On October 5, 2007, three-time Olympic gold medalist for track and field Marion Jones admitted to use of the drug, and was sentenced to six months in jail for lying to a federal grand jury in 2000. 
Side effects caused by Flonase and Nasonex are similar and include a headache; stinging, burning or bleeding in the nose; a sore throat and watery eyes. The American Academy of Asthma, Allergy and Immunology (AAAI) warns that fluticasone nasal sprays (Flonase) do slow growth rate in children; one large study of 474 children reported an average slowing of cm/year (as much as cm and as little as cm). While other studies that investigated mometasone (Nasonex) did not find it slowed growth rate, it is likely that numbers of participants in these trials were too few to show a difference. All children receiving intranasal corticosteroids for longer than two months should be monitored for any slowing of growth rate.