Metabolic effects occurring during anabolic steroid therapy in immobilized patients or those with metastatic breast disease include osteolytic-induced hypercalcemia.
Anabolic steroids effect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred during anabolic steroid therapy.
The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.
Significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL) have occurred. [ Ref ]
Also, medical advice should be sought if the person has previously suffered heart attack, has a disease of the blood vessels or the heart, has high cholesterol levels in the blood, has clotting or excess bleeding problems, or has diabetes, kidney, or liver diseases. If the person has one or more of these problems, then an alteration of the dosage may be required. Medicines that can react with Winstrol are blood thinners or anticoagulants, diabetes medication, and insulin. Care should be taken while administering Winstrol with any of these medicines.