Winstrol is hepatotoxic, and because of this, it should be used at the lowest effective dose for the shortest possible cycle. What’s more, you should consider using a supplement designed to provide some additional protection. Milk thistle is a highly recommended option; studies suggest it can provide an effective layer of protection when it is used for the entire length of your cycle. There are some other supplements on the market, such as Liver Care, which are blends of natural ingredients that have been shown to work together to prevent liver toxicity.
For women, things are a bit different. They do not need SERMs because they produce so little testosterone naturally that suppression isn’t as detrimental. However, Anavar and Winstrol act much like testosterone in the female body, and using the combination over the course of four to six weeks can create a hormonal imbalance. Women who simply come off steroids cold turkey, even after a few weeks, may notice undesirable effects like fatigue and irritability. To avoid this, simply reducing dose toward the end of the cycle can help tremendously.